The electronics behemoth verified President Yoon Suk Yeol's Wednesday announcement.
In 20 years, Gyeonggi province, part of the Seoul Metropolitan region, would build the chip cluster.
To safeguard intellectual property, the Industrial Technology Protection Act will be updated.
Samsung aims to invest $350 billion in core sectors like chipmaking and biopharmaceuticals by 2026.
CLSA analyst Sanjeev Rana estimates Samsung's 20-year investment plans at 15 trillion won per year.
Samsung's semiconductor, electronics, and medical industries are rising due to global chip shortages.
Samsung Electronics' Pyeongtaek chip factory from above on September 7, 2022. Samsung/Reuters/File
China-U.S. political and economic conflicts threaten semiconductor availability for global economies.
Washington and Apple have urged semiconductor businesses to localise.