Creighton advances to the Elite Eight for the first time since 1941 after defeating Princeton.
Ryan Kalkbrenner and Baylor Scheierman led the Bluejays with a combined 43 points.
San Diego State will be Creighton's next opponent in the South Region final.
Kalkbrenner was briefly benched in the first half due to attitude issues.
Princeton was led by Ryan Langborg and Tosan Evbuomwan with 26 and 24 points, respectively.
Princeton upset No. 2 seed Arizona and No. 7 seed Missouri in the tournament.
The Tigers were seeking to become the first Ivy League champ to reach the Elite Eight since 1979.
Creighton used a 9-2 run in the second half to take control of the game.
The margin of defeat for Princeton's game was 11 points. The Tigers were unable to stage a comeback.
Creighton now has a chance at a program-changing victory in the Elite Eight.
Creighton's offense and defense have both improved under coach Greg McDermott.